Cancer of Breast - Cancer Research Project - Ayurved Hospital and Research Center - Bharatiya Sanskriti Darshan Trust .:Ayurveda for Cancer:.

Case 1

Remarks by Oncologist After Ayurvedic Treatment

This is 63 years old patient of carcinoma of breast, stage III, post surgery. In this case after 2 years of remission metastatic development was seen in right supra clavicular lymph node, post radiation (July 98). After 1 year 4 months again metastasis was seen in cervical lymph node, post chemotherapy (November 99). In this case complete remission is seen for 12 years 10 months of Ayurvedic treatment after second metastasis. Patient could complete chemotherapy and radiation with minimal side effects. MRI, bone scan, chest X ray and USG are within normal limits. No recurrence is seen after November 99. Observed 10 year survival in this type of cases is 31%. Her Karnofsky score is 100 and ECOG score is 0.

Name:	RHK
Registration No:	961158	Sex:	F
Age at Registration:	63 yrs	Age at Diagnosis:	63 yrs
Group:	C (group B – 10/7/98)
Diagnosis:	Carcinoma of breast, stage III, (August 96). Metastasis in right supra clavicular lymph node (July 98). Metastasis in cervical lymph node,(Nov. 99).
HPR:	19 Aug 96 – Lump in right breast Infiltrating duct carcinoma. Grade III (R.B. Score 3,2,3) with desmoplasia. Occasional focus of intra duct carcinoma is seen. Small foci of necrosis are seen. Lymphatic emboli are noted. Tumour involves the margin of excision. ER, PR – negative. July 98 – Right supra clavicular lymph node biopsy Metastasis of adenocarcinoma consistent with primary in the breast. November 99 – Right posterior triangle lymph node biopsy Metastatic carcinoma consistent with known breast primary. Two negative nodes also seen. ER, PR – negative.
	Tx N2 Mo
Date of Diagnosis:	16/8/1996

Previous History:

Hysterectomy at 45 years of age.

Treatment History:

Surgery – Right breast lumpectomy done on 9/8/1996.

Chemotherapy – 3 cycles taken from 23 August 1996 to Nov 1996

Inj. Endoxan 1 gm
Inj. 5 FU 18 mg
Inj. Epirubicin 75 mg

Surgery – Quadrectomy with axillary clearance done on 5/11/96.
Chemotherapy – 3 cycles taken from Dec 96 to Apr 97

Inj. Endoxan 1 gm
Inj. 5 FU 18 mg
Inj. Epirubicin 75 mg

Radiation taken from December 96 to January 97 at right breast and axilla.
4500 cGY/ 25 #/ 42 days
Right supra clavicular lymph node Recurrence
Radiation from July 98 to Aug 98
Right posterior triangle lymph node recurrence
Chemotherapy – 3 cycles taken from December 1999 to February 2000.

Inj. Intaxol 100 mg
Inj. Carboplatin 150 mg

Ayurvedic Treatment Started on:	7/9/1996
Status:	Post lumpectomy, after 1 chemotherapy cycle.
Total duration:	12 years and 10 months	Last Follow up:	18/7/2009

Symptom when Registered in the project:

Weakness.
Loose motions

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
Weakness.	3	0
Loose motions	3	0
G.C.	7	9
Pain	3	0
Weight	53 kg	50 kg

Case 2

Remarks by Oncologist After Ayurvedic Treatment

This is 37 years old patient of carcinoma of breast (January 2001) and metastasis in liver, post chemotherapy (December 2001). In this case complete remission is seen for 7 years 6 months of Ayurvedic treatment. Patient could tolerate chemotherapy very well with minimal side effects. Regression is seen in CT scan of abdomen. In patients such as this observed survival is less than 2 years. Her Karnofsky score is 100 and ECOG score is 0.

Name:	RAP
Registration No:	20021004	Sex:	F
Age at Registration:	37 yrs	Age at Diagnosis:	37 yrs
Group:	C
Diagnosis:	Carcinoma of breast (25.12.2001). Metastasis in liver (27.12.2001).
HPR:	25.12.2001 – Left breast duct carcinoma cells. 27.12.2001 – Liver FNAC – Metastatic adenocarcinoma consistent with carcinoma of breast.
Date of Diagnosis:	25/12/2001

Treatment History:

Chemotherapy – 6 cycles taken from 4/1/2002 to 18/4/2002.

Inj. Adriamycin 80 mg.
Inj. 5 FU 800 mg.
Inj. Endoxan 800 mg.

Hormonal therapy started since may 02 to may 07

Tab. Tamoxifen 10 mg BD.

Ayurvedic Treatment Started on:	12/1/2002
Status:	Ongoing chemotherapy
Total duration:	7 years and 6 months	Last Follow up:	10.7.2009

Symptom when Registered in the project:

Pain in abdomen
Haematuria
P/R Bleeding
Burning sensation at Anus
P/V Bleeding.
Loss of appetite.

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
Pain in abdomen	4	0
Haematuria	4	0
P/R Bleeding	2	0
Burning sensation at Anus	4	0
P/V Bleeding.	4	0
Loss of appetite	4	0
G.C.	7	9
Pain	4	0
Weight	68 kg	68.5 kg

Investigations – CT scan abdomen –

27/12/01 (Before Ayurvedic Treatment )	Multiple metastatic lesions seen involving all segments of right lobe with large mass occupying virtually the entire right lobe inferior involving segment IV and V (mass size 11 x 8 cm necrotic mass).
26/04/02 (after chemotherapy & 3 months after Ayurvedic Treatment )	There appears regression of all small metastatic nodules in liver except the nodule in anterior segment of right lobe. Large irregular mass in right lobe also shows moderate decrease in size and now appears dense in relation to fatty liver parenchyma hence may represent fat spared regenerating tissue rates than residual tumor. (mass size 6.5 x 3 x 5.6 cm).
24/05/04 (after 2 years and 4 months of Ayurvedic treatment.)	Study within normal limits except for diffuse fatty infiltration in liver. No significant abnormality noted.

USG abdomen –

17/12/01	Mild hepatomegaly. Right lobe of liver shows increased and inhomogeneous echo texture. ? A calculus, cholecystitis. No renal calculus or hydronephrosis .Bulky uterus with thickened endometrium. No free fluid in abdomen.
22/07/06 (after 4 years and 6 months of Ayurvedic treatment.)	Bulky Uterus. Endometrial hyperplasia (30 mm). Fatty infiltration of liver. No obvious focal lesion is detected. No lymphadenopathy or ascites.
6/02/07 (after 5 years and 1 months of Ayurvedic treatment.)	Diffusely thickened Endometrium (15 mm) No mass or irregularity. No abdominal or pelvic mass or collection. Mild hepatomegaly with fatty grade II changes.
28.01.08 (after 6 years of Ayurvedic treatment.)	Bulky uterus with thickened endometrium – 13 mm.
19.12.08 (after 6 years 11 months of Ayurvedic treatment.)	Right renal calculi, liver fatty changes

Tumour marker (CA 15.3 – 0-35 U/ml) –

14.11.08
(after 6 years 10 months of Ayurvedic treatment.)
10.7.2009
(after 7 years 6 months of Ayurvedic treatment.)

4.7 U/ml Report awaited

Case 3

Remarks by Oncologist After Ayurvedic Treatment

She is 50 years old patient, a case of carcinoma of breast, stage III, post surgery and chemotherapy. Complete remission is seen in this case for 10 years & 8 months with Ayurvedic treatment. Patient could tolerate chemotherapy with out any side effects. No recurrence is seen. CT scan of abdomen, bone scan and mammography are within normal limits. Her last follow at tata memorial hospital in July 08 was normal. Observed 10 year survival rate in cases of stage III carcinoma of breast is 38%. Her Karnofsky score is 100 and ECOG score is 0.

Name:	BKM
Registration No:	971118	Sex:	F
Age at Registration:	50 yrs	Age at Diagnosis:	50 yrs
Group:	C (C to D – November 1998)
Diagnosis:	Carcinoma of breast, stage III.
HPR:	Infiltrating duct carcinoma grade III. Cribiform DCIS component is also noted 1/13 nodes show micro-metastasis. ER, PR negative.
Date of Diagnosis:	09.10.97

Treatment History:

Surgery – MRM of left breast done on 15/10/97.

Chemotherapy – 8 cycles taken from November 1997 to May 1998.

Inj. Cyclophosphamide 800 mg
Inj. Adriamycin 50 mg
Inj. 5 FU 800 mg

Hormonal therapy with Tab. Tamoxifen was started but stopped due to side effects after 8 days.

Ayurvedic Treatment Started on:	15/11/97
Status:	Post surgery, after 1 chemotherapy cycle.
Total duration:	10 years and 8 months	Last Follow up:	28.07.08

Symptom when Registered in the project:

Asymptomatic

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
G.C.	8	9
Pain	0	0
Weight	52 kg	52 kg

Investigations – USG abdomen

31/07/98 (after surgery, chemotherapy and 9 months of Ayurvedic treatment.)	Within normal limits.
6/02/99 (after 1 year and 2 months of Ayurvedic treatment.)	Within normal limits.

Investigations – Mammography

28/7/2008 (after 10 years and 8 months of Ayurvedic treatment)

Within normal limits.

Case 4

Remarks by Oncologist After Ayurvedic Treatment

This is 58 years old case of carcinoma of breast, stage III, post surgery. In this case complete remission is seen for 13 years & 2 months of Ayurvedic treatment. Patient is now asymptomatic and USG, chest X ray show no recurrence. Observed 10 year survival in cases of stage III carcinoma of breast is 47%. Her Karnofsky score is 100 and ECOG score is 0.

Name:	SRA
Registration No:	961058	Sex:	F
Age at Registration:	58 yrs	Age at Diagnosis:	57 yrs
Group:	D
Diagnosis:	Carcinoma of breast, stage III.
HPR:	Infiltrating duct carcinoma of left breast grade II. 3/13 axillary lymph node are metastatic.
Date of Diagnosis:	20/2/1995

Previous History:

Hormonal treatment for 8 years for conception.
Diabetes since 55 years of age.

Treatment History:	Surgery – MRM of left breast done on 9/3/95.
	Hormonal therapy with Tab. Tamoxifen 10 mg BD taken from March 1995 to March 2000.

Ayurvedic Treatment Started on:	13/4/1996
Status:	Post surgery, on oral chemotherapy.
Total duration:	13 years and 2 months	Last Follow up:	28/6/2009

Symptom when Registered in the project:

Pain in right hypochondrium region.
Flatulence.

Panchakarma Treatment:

Set A – from 23/1/2001 to 9/2/2001

Kal Basti Krama completed from 23/1/2001 to 9/2/2001.

(Anuvasan – Tila Taila 50 ml
Niruha – Dashamoola Kwatha 700 ml + Madhu 10 ml + Saindhav 100 mg)

Set B – from 15/9/2003 to 2/10/2003

Kaal Basti Krama completed from 15/9/2003 to 2/10/2003.

(Anuvasan – Sahachara Taila 50 ml
Niruha – Dashamoola Kwatha 500 ml + Madhu 10 ml + Saindhav 100 mg)

Symptoms	Gradation Before Treatment	Gradation After Treatment
Pain in right hypochondrium region.	3	0
Flatulence.	2	0
G.C.	8	9
Pain	3	0
Weight	89 kg	88 kg

Investigations:
Mammography: (Bilateral) –
06.02.95 (Before Ayurvedic Rx – During Diagnosis)	Left breast – multicentric carcinoma with left axillary nodal mets
01.02.08 (After 11 yrs 8 months of Ayurvedic Rx)	Right breast WNL
PET Scan
05.11.96 (After 7 months of Ayurvedic Rx)	Left Calcanial lesion – benigh cause.
USG Abdomen
20.11.95 (Before Ayurvedic Rx)	Mild hepatomegaly with fatty infiltration.
17.01.08 (After 11 yrs 7 months of Ayurvedic Rx)	Mild hepatomegaly with fatty infiltration.
Tumor Marker (CA 15.3)
28.07.08 (After 12 yrs 1 months of Ayurvedic Rx) 5.6.09 (After 13 yrs of Ayurvedic Rx)	27.5 U/ml 9.9 U/ml
Xray Chest
17.01.08 (After 11 yrs 7 months of Ayurvedic Rx)	Left mastectomy noted. Rest NAD

Case 5

Remarks by Oncologist:	This is 40 years old female patient of carcinoma of breast, stage III b, post surgery and chemotherapy. In this case complete remission is seen for 5 years 2 months of Ayurvedic treatment. Observed 5 year survival of this type of patient is 58%. Her Karnofsky score is 90 and ECOG score is 1.
Remarks by Ayurvedic Physician:	This is a post operated, post chemotherapy case of Vama Stana – Dushta Medoja Arbuda and Dushta Granthi as Upadrava (1/2). She was under oral hormonal treatment for next 2 years. She was suffering from Urdhwaga Amlapitta since last 8 years. Kamadudha Rasa and Praval Pishtee were used due to their Pitta Shamaka action. Aarogyavardhini was used to prevent recurrence due to its Rasa and Mansa Dhatwagni Deepak and Rasa and Mansa Dhatu Shodhak action, as the site of Dushta Mansarbuda was Stana (breast) which is the Upadhatu – Stanya (breast milk) of Rasa and the Arbuda was Dushta Mansa dominant. Kushmanda is Rasayana for Rasa Dhatu and useful in Amlapitta. Paushtik Ladu is Balya (gives strength).

Name:	KGK
Registration No:	20010129	Sex:	F
Age at Registration:	40 yrs	Age at Diagnosis:	39 yrs
Group:	C (group D – 28/4/2003)
Diagnosis:	Carcinoma of breast, stage III b, post surgery, chemotherapy.
HPR:	Invasive intra ductal carcinoma – low grade (IDC – NOS type) with metastasis to one out of two lymph nodes.
Date of Diagnosis:	1/11/2000

Previous History:

Hyperacidity since 8 years.

Treatment History:

Operated for MRM of left breast on 24/10/2000

Chemotherapy 5 cycles given from 16/11/2000 to 29/3/2001

Inj. Cyclophosphamide 800 mg
Inj. Adriamycin 60 mg
Inj. 5 FU 1 gm

Hormonal therapy with Tab. Tamoxifen 10 mg BD for 2 years

Ayurvedic Treatment Started on:	23/10/2001
Status:	Post surgery, post chemotherapy
Total duration:	5 years and 2 months	Last Follow up:	7/12/2006

Symptom when Registered in the project:

Weakness
Loss of appetite
Irregular menstrual cycle

Treatment given:

Set A – From October 2001 to November 2005

Morning and evening – Kamadudha 250 mg + Praval Panchamrut 250 mg with milk
After lunch and dinner – Aarogyavardhini 500 mg + Sharapunkha 500 mg with water

Set B – From December 2005 onwards

Morning – Kushmanda Pak 5 mg with milk
Evening – Paushtik Ladu 5 mg with milk

Panchakarma Treatment:

From 21/7/03 to 1/8/03

Bahya Snehana done with Tila Taila from 21/7/03 to 31/7/03.
Bahya Swedana done with Dashamoola from 21/7/03 to 31/7/03.
Yoga Basti Krama – from 21/7/03 to 27/7/03.

(Anuvasan – Tila Taila 60 ml + Saindhav 5 gm
Niruha – Kwatha 500 ml – Dashamoola, Triphala, Madanphala + Tila Taila 80 ml + Madhu 25 ml + Saindhav 5 gm)

Bruhana Basti – from 28/7/03 to 1/8/03.

(Pancha Tikta Ksheer 300 ml + Pancha Tikta Ghruta 20 ml)

Treatment Analysis

Symptoms	Before Treatment	After Treatment
Weakness	4	1
Loss of appetite	4	0
G.C.	8	9
Pain	3	2
Weight	64 kg	60.5 kg

Case 6

Remarks by Oncologist After Ayurvedic Treatment

This is 42 years old patient of carcinoma of breast, stage II, post surgery. In this case complete remission is seen for 9 years & 6 months of Ayurvedic treatment. No recurrence is seen. Bone scan, chest X ray, sonography of abdomen are within normal limits. Observed 10 year survival rate in cases of stage II carcinoma of breast is 71%. Her Karnofsky score is 100 and ECOG score is 0.

Name:	HD
Registration No:	961171	Sex:	F
Age at Registration:	42 yrs	Age at Diagnosis:	42 yrs
Group:	C (group D February 1997)
Diagnosis:	Carcinoma of breast, stage II
HPR:	Infiltrating duct carcinoma with desmoplasia. Adjacent breast shows cystic and apocrine change.
Date of Diagnosis:	21/6/96

Previous History:

Hysterectomy done for uterine fibroid at 39 years of age.

Treatment History:	Surgery – lumpectomy of left breast done on 21/6/96.
	Surgery – MRM of left breast with axillary clearance done on 12/7/96.

Ayurvedic Treatment Started on:	28/9/1996
Status:	Post surgery
Total duration:	9 years 6 months	Last Follow up:	05.03.2006

Symptom when Registered in the project:

Pain in left hand.
Pain in chest region.
Urticaria
Weakness
Insomnia

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
Pain in left hand	3	0
Pain in chest region	3	0
Urticaria	3	0
Weakness	3	0
Insomnia	3	0
G.C.	7	9
Symptoms	Gradation Before Treatment	Gradation After Treatment
Pain	3	0
Weight	64 kg	60 kg

Investigations:
USG Abdomen
30.12.97 ( 1 yr 3 months after ayurvedic Rx)	NAD
23.05.98 ( 1 yr 8 months after ayurvedic Rx)	NAD
HPR (Left MRM)
30.08.04 (After 7yrs 11 months of Ayurvedic Rx)	There is no e/o malignancy
Bone Scan
17.04.03 (After 6 yrs 5 months of Ayurvedic Rx)	NAD

Case 7

Remarks by Oncologist After Ayurvedic Treatment

This is 36 years old patient of high grade intra ductal carcinoma of breast, stage II, post surgery. In this case complete remission is seen for 4 years & 9 months of Ayurvedic treatment. Chest X ray, USG and mammography do not show any recurrence or metastasis. Observed 4 year survival in this type of cases is 89%. Her Karnofsky score is 90 and ECOG score is 1.

Name:	JSG
Registration No:	20021108	Sex:	F
Age at Registration:	36 yrs	Age at Diagnosis:	36 yrs
Group:	C (C to D – Feb 2003)
Diagnosis:	Carcinoma of breast, stage II.
HPR:	Intraductal high grade carcinoma of left breast. Axillary nodes – all 17 lymph nodes are negative for tumour. Apical tissue – all 3 nodes are negative , ER- PR : Negative, T2NoMo
Date of Diagnosis:	02/08/2002

Previous History:

Natural abortion in 1994.

Treatment History:

Surgery – MRM of left breast with axillary lymph node clearance done on 6/8/2002

Ayurvedic Treatment Started on:	19/10/2002
Status:	Post surgery
Total duration:	4 years and 9 months	Last Follow up:	21.07.2007

Symptom when Registered in the project:

Weakness
Pin prick sensation at the operated site
Pain in left hand

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
Weakness	3	0
Pin prick sensation at the operated site	5	1
Pain in left hand	3	0
G.C.	7	9
Pain	4	0
Weight	54 kg	50 kg

Investigations – USG abdomen and pelvis

1/10/03 (after 1 year of Ayurvedic treatment)	Within normal limits.
20/10/04 (after 2 years of Ayurvedic treatment)	Within normal limits.
1/09/05 (after 2 years and 11 months of Ayurvedic treatment)	The calcific foci in the liver are likely to represent old dystrophic calcification. No evidence of metastasis. No other abnormality is seen.
6/04/06 (after 3 years and 6 months of Ayurvedic treatment)	Tiny hepatic focal calcification.
22/05/06 (after 3 years and 7 months of Ayurvedic treatment)	Within normal limits.
29/09/06 (after 3 years and 11 months of Ayurvedic treatment)	Tiny hepatic focal calcification.

Case 8

Remarks by Oncologist After Ayurvedic Treatment

This is 43 years old patient of carcinoma of breast, stage II, post surgery and chemotherapy. In this case complete remission is seen after 3 yrs & 6 months of Ayurvedic treatment. No side effects of chemotherapy were seen. Observed 3 year survival in this type of cases is 91%. Her Karnofsky score is 100 and ECOG score is 0.

Name :	AUK
Registration No :	20041075	Sex:	F
Age at Registration :	43 yrs	Age at Diagnosis:	43 yrs
Group :	C (C to D July 2005)
Diagnosis :	Carcinoma of Left breast, stage II A
HPR :	Infiltrating lobular carcinoma, grade II. ER + , PR +,
	T2 NoMo
Date of Diagnosis :	9/9/2004

Previous History :

Chicken pox, measles and jaundice in childhood.

Treatment History :

Surgery – MRM of left breast done on 16/9/2004

Chemotherapy – 6 cycle taken from 8/10/2004 to 24/1/2005

Inj. Epirubicin 140 mg
Inj. Endoxan 800 mg
Inj. 5 FU 750 mg

Hormonal therapy with
Tab. Tamoxifen 10 mg BD from January 2005 to Jan 07.
Tab. Letroz 10 mg OD from Jan 07 onwards.

Ayurvedic Treatment Started on :	23/10/2004
Status :	Post surgery, completed 1 cycle of chemotherapy.
Total duration :	3 years and 6 months	Last Follow up : 26.04.08

Symptom when Registered in the project :

1. Nausea
2. Loss of appetite
3. Weakness
4. Fatigue

Treatment Analysis

Symptoms	Gradation Before Treatment	Gradation After Treatment
Nausea	3	0
Loss of appetite	3	0
Weakness	3	0
Fatigue	3	0
G.C.	7	9
Pain	3	0
Weight	58 kg	58.5 kg

Investigations – Mammography

19/10/2005 (after 1 year of Ayurvedic treatment)	Small benign lesion infero–medially in the right breast. Benign lesion supero–laterally in the right breast, suggestive of Fibroadenoma.
25/9/2006 (after 1 year and 11 months of Ayurvedic treatment)	Benign findings of Fibroadenoma in right breast.
05/11/2007 (after 3 year and 1 months of Ayurvedic treatment)	Right breast lesion superolaterally s/o – fibroadenoma – increased in size than in previous mammography.